YOU ARE HERE: HOME
Welcome to the Imidazole Library
This website houses a library of imidazole based compounds. The imidazole core structure provides the basis for the design of potentially bioactive compounds. Imidazole-4,5-dicarboxylic Acid [I45DA] is the scaffold from which the derivatives are synthesized. Using I45DA, imidazole derivatives that mimic biologically active compounds such as proteins, peptides, and nucleic acid bases are synthesized. Early work by Dr. Paul Baures in the 1999 Volume 1 issue of Org. Letter reported modest inhibitory activity of N,N'-Imidazole-4,5-dicarboxamide [N,N'-I45DC] in a study of heterocyclic HIV-1 protease inhibitors. Additional work in 2005 by Elisabeth Perchallet, Jean-Pierre Perchallet, and Dr. Baures published in the Journal of Medicinal Chemistry [Vol. 48] illustrated that N,N'-disubstituted I45DC exhibited antiproliferative activity against HL-60 cells (cancer cells). The synthesis of this imidazole library could potentially lead to other bioactive compounds. The development of this website can harness this information and aide in its dissemination to the scientific community so that others may build on our findings.
National Institute of Health submission and screening
The imidazole compounds synthesized for this library are submitted to the National Institute of Health [NIH] repository for use in screening through the Molecular Libraries Screening Center Network [MLSCN]. Our compounds specifically are sent to the Molecular Library Small Molecular Repository. BioFocus® DPI, a Galapagos company, operates MLSMR in South San Francisco. All of the biologically active compounds from our library are being registered in the publicly accessible database PubChem. PubChem offers searchable structures, other relevant information about each compound, and all screening data as it is generated by the NIH Roadmap Molecular Libraries Initiative [MLI]. In PubChem, select search "PubChem Substance" and enter "MLSMR" as the search criterion to view the current set of Repository compounds.